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I have a doubt, in an isometric topdown project, where only the characters, npcs will be 3d would it be possible to reach something professional using the plugin, taking into account having an average of 500 to 1k of 3d models on the same map

it’s hard to know without the specifics, but if they are complex models, 500-1000 onscreen would be tough on reasonable PC. If they are not on screen though, there is almost no perf required, so depends on the game and what is in view.