Can you provide more details as to the error messages you're seeing? Our test unzipping all of the included files in the free trial Zip file into C:\pixelcnc\ works on Windows 10 machines. The unknown publisher warning is standard for unsigned executables and should not be preventing you from running the program entirely unless something else is explicitly blocking unsigned software from running, such as User Account Control, Windows Defender, or something related.
Two alternative options are to either run PixelCNC as administrator and/or putting the PixelCNC folder somewhere else on your harddrive that is not accessible only by administrators, such as your Desktop, Documents, or user account folder. PixelCNC does not require administrator access for anything because it does not write to anywhere outside of the current user's files for writing a config file and log file but there have been reports of running as administrator being required just to get it to run, which is something that will be resolved when PixelCNC moves to the beta phase of development.
I would recommend against running any software as administrator if possible by moving the folder to another location that the current Windows user account has access to (i.e. the user account's folder), but this is not a surefire guarantee that it will prevent Windows 10 from requiring the program run as administrator.