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Nah. The quest sequences are nearly impossible to break.

If you happen to find a way, totally report that as a bug. heh

Don't forget to Mention Arlene, the Sadistic Cop. 

You need her to be on Your side.

how do i get on arlene on my side

Pay a Beggar 2K Credits then sleep, go to the Beggars again and ask Around, read the Dialogue they give necessary Clues.

are the beggars the pore people

Under the Don's home yes, they don't like the Don just make sure to Recheck if they are really Causing the Riot, Via speaking to them, or Talking to Arlene.