Well, it's a windows application with only the windows version of cefpython. This is well into trying to port it to linux, which I haven't attempted! I hear it runs under Proton but not under Wine, so that would be your best bet.
Transplanting a linux build of cefpython in there might work, but probably not without modification. Maybe the current directory is wrong for chromium's subprocess to find all its bits? If so, that's weird because I've run the game using a cefpython3 in site-packages before. Hmm, dunno.