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I just cannot get past floor 21 no matter how good of a run I am on. The difficulty jumps so much... Any tips? I have been cruising through with block pieces but I think I need to be able to one shot enemies after 21. It gets pretty frustrating since I am literally not taking any health damage all the way to 21 and then just get smacked.

you need reusable healing and a deck with only 5 dice and be able to loop full heal plus shield while chipping in dmg