I love the look and feel of the game! Right off the bat having Death being annoyed that you interrupted his birthday is just hilarious! One thing I might suggest is that you may want to make power-ups disappear completely once the player has found them, even after death. That way it's a bit more clear that they don't need to collect them again.
I know it's beating a dead horse at this point, but the controls are just weird. Having all of those left click combos right off the bat just feels awkward, and I would agree with some of the other players here that it would be better just to move all of the mouse functions to keyboard keys. I haven't beaten the game because I just can't wrap my head around it yet, though I'm going to give it another try soon.
One last thing: I hope you'll consider making a downloadable version of this. I love playing these games offline, and with a dedicated exe file I could remap all of these different functions to a controller with Xpadder. That would make things a bit easier to work with regardless of the control scheme.