Manual unzipping gives:
AfterHours
--> empty
LD43_Data
--> a couple directories and a bunch of files
Mono
--> two directories
LD43.exe (run this one)
UnityCrashHandler64.exe
UnityPlayer.dll
Viewing post in After Hours: A Reverse Metroidvania comments
It's strange that you have an Empty AfterHours folder. Can you try running the game through the itch app?
https://itch.io/app