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Could you tell me which item(s) did you use? 

Sure let I'll look it up I kept the items because I didn't want to waste them. They still in my inventory I'll look them up and post them in my next comment.

The innocent herb,impure herb, and eternal drug.  When I use them I check appearance after, and nothing changes. The orbs work, I used the Minotaur orb and the Werewolf orb and I had no issues. 

Also the forest monster The Nue I think its name was seems really strong. When I try to attack it with temptation or skills I can't do any damage. I only have four skills unlock. My character is equiped with Iron Dildo, Fundoshi, Headband, Sparrow ring and Sparrow Amulet. I don't know if the creature is unkillable or if I'm just too weak?

Thank you for your report! We'll check the effects of the items and update if there is a bug.
About Nue, you can beat it. If Nue is too strong, please visit him after you get cooperation of companions in various locations. When you get cooperation, you can learn 'Art'. Some 'Art' are very strong for beating Nue. 

Also the vigor pepper and longevity drug aren't working? I guess its or something, there was a item that increased the ball size and body hair that didn't work but I don't remember what it is called. The body changing items rarely work for me except for the workout those work and I have no issues with the orbs.

Ok, we will check these items too. Thank you for your information!