Thank you for your report! We'll check the effects of the items and update if there is a bug.
About Nue, you can beat it. If Nue is too strong, please visit him after you get cooperation of companions in various locations. When you get cooperation, you can learn 'Art'. Some 'Art' are very strong for beating Nue.
Also the vigor pepper and longevity drug aren't working? I guess its or something, there was a item that increased the ball size and body hair that didn't work but I don't remember what it is called. The body changing items rarely work for me except for the workout those work and I have no issues with the orbs.