Okay, first of all, too much screen shake. Way too much screen shake. It made my eyeballs hurt and my stomach's a little upset after playing it. Please use more discretion in the future with effects like this. There are a lot of people who will find a game like this unplayable. It's fine to play around with making your players a little uncomfortable, but it's important to know when to stop.
With that gripe out of the way, the core concept here is great. I love that there is a new twist every time. I'd love to see you develop this game more.
With the hope of seeing you develop the game into a full release in mind, I have a couple of suggestions.
It didn't seem like the health bar over the player reflected their actual remaining health. I would suggest retooling this so the bar is an accurate gauge.
The walls stop the player and the enemies, but not projectiles. Consider making the projectiles stop at the walls, or perhaps in certain twists they could even bounce off the walls and continue their trajectories?
Moving from room to room quickly became repetitive, due to there not being an overarching goal to reach for. Consider also randomizing the goals- "Survive X seconds without killing all the enemies (or without killing any enemy?)," "Reach the exit within X seconds," "Don't touch any of the walls," or "Clear X rooms in Y seconds" would all be good goals, in my opinion. At minimum, a counter of rooms cleared would help make the game feel like it had more of a goal to strive for.
The enemy types also became repetitive. Consider adding enemies that have other movement patterns, such as those that stay away from or kite the player, those that shoot projectiles, and those that work together to form an impenetrable wall the player must dismantle to proceed.
Overall, you did very well in this game jam. This is a strong contender for a top spot, in my opinion. Your core concept fits the theme well, and you managed your time wisely to complete a working and pretty polished prototype in the 3 hours the jam suggests. Great job!