Hi! What setup did you use with VirtualBox? I can verify it works on my machine if you create a following VM:
- Type: Other, Version: Other/Unknown for i686 or Other/Unknown (64-bit) for x86_64
- 128 MB of RAM (looks like this defaults to 64, which is a bit surprising)
- Do not add a virtual hard disk, click continue on the prompt asking if you are sure
On the first boot it will either tell you to select a disk to boot it from, or tell you "FATAL: Could not read from the boot medium! System halted". If latter, go to Devices → Optical drives → Choose a disk file. Choose either switcher-i686.iso or switcher-x86_64.iso depending on which kind of machine you created.
After this, you should be able to go to Machine → Reset and boot the game. If some of the game window is obscured, you can resize the VirtualBox window.
If you have any further questions or problems getting Switcher going, do tell me.