I really like the concept of the game, and it's a cool interpretation of the theme! As annoying as it was that bugs kept showing up, I thought it was cool how how they were designed and integrated. I couldn't beat the second level when bugs start to appear!
I'm on a Mac using a wireless Logitech mouse (which has been annoying with some games in the past), but I felt like I was spamming the mouse wheel or arrows to change the color. The color changes are so minor I think the game would benefit from some other form of feedback to let you know that something is happening.
Lastly, I agree with what others have said about how the game is packaged. While I had zero problems installing this (I have plenty of coding experience) I can see where 1) it might be difficult for some or 2) people may not be comfortable installing a bunch of scripts where they're concerned about security.
Aside from those issues, I had fun, and enjoyed the challenge!