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I think that it is common for Z to be the 'main' button on pc games where the arrow keys are used. Since the 'd-pad' is on the right you can kind of think of the entire controller as being reversed. There's no perfect solution but it shouldn't take too long to get used to.

I see what you mean. To avoid this I've started doing both Z & C as the A button, allowing people to choose their preferred layout.

Interesting! In projects where I spent a lot more time on setting them up I've done stuff like making sure WASD will work etc. Ideally people will just download the rom and map the keys however they want in an emulator though.