One weird thing I have noticed, when you get a tilt some tiles will not be active for several turns afterwards. They become also ghost tiles.
The center tile pictured below would not connect to pips. It was like the tile wasn't there but still took up physical space. When a tile was put into play the ghost tile would not activate in combos but would allow the combo to pass through.
And then a few turns later, they would start behaving like normal tiles again.