Results look identical if you scale by a multiple of two and if you use nearest interpolation on your textures. It's faster, too.
Viewing post in Question about manual sprite assets management
But that is not what the creator of the topic is asking about. He is talking about a image one pixel taller being noticed. If you are noticing that squishing it down by one pixel or the others up by one pixel may not look good. He can obviously just try it but I would rather do than manipulation by hand.