Other games in general, or other Renpy based VNs? The only known issue that's like what you're describing is a Renpy-specific rendering issue or a GPU driver issue. Hopefully it's just the Renpy side cause there's a solution:
1. Open the game
2. Press Shift+G (This will open a Renpy debug menu)
3. Select ANGLE2 Renderer. Close and re-open the game and it should work.
If the menu is still screwy here, the option you want is the top-left most option.