First of all, 0.2.11 will hopefully fix the late-game balance.
As for tips: make a lot of CPUs especially early on (high CPU levels are very useful), marketing is a blessing (a couple of maxed out campaigns shouldn't ever hurt), and perhaps you're pricing your products wrong? It's often beneficial to sacrifice a bit of score for higher profit margins and vice-versa.
My pricing is similar to my competitors but my cpu is about 25% better and cheaper BUT no ppl still decided to buy from a worse version of my product more than mine which is about 17% for some reason and reviewers say its TOO pricy when something worse and 50 bucks more expensive than mine they say its wOrtH the sacrifice. just died again in my hardmode run made it 2005 as soon you commented.