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The other modes are easier than the default mode on purpose (except the solo mode maybe). The sandbox mode is the easiest. The early game is difficult. On the number of Guild quests, they increase as your guild rep increases, at 500 rep you get two and at 1000 rep you get three.  To get to 500 quicker, on day go to each guild upgrade page and set the quest difficulty to Medium. These quests give more rep.

I've tried the  "med"   Quest setting before----got crazy stuff like  "Mythic leather"    (still no idea where to even buy/mine the stuff!)      or large amounts of Obsedian.    Oh,   tried "solo"   just for kicks---not much difference------as mentioned most BAD luck is with Quests    (1st 21 days)  
Having the option to *CANCEL*   (& get a different  one) might help a LOT on same cases.     [like "Dungeon clear"   to start instead of Wolves   (can't rem quest name)  or items that you need Upgrades for that you don't have (& can't find to buy) }

"Guild Quest" #?        It's actually backwards-----by the time I get to 1,000+,     [past D28]  they don't matter anymore;   (strong enough to fight/have enough upgrades etc)  More about facing the Lich    (bypassed him b4 but just doesn't seem right to go ----& not fight    ;-)   ]
Might also help if Quests didn't EXPIRE so soon!    (like "Dungeon clear" at very beginning----heal/earn gold buy potions  etc )