It "just works" with the caveat that without a Mac, you can't sign and notarize the build. So users who download it will have to remove it from quarantine and jump through some hoops to get it to run on macOS Catalina and newer.
But by now that's something many might be used to with indie projects. If you make it clear to users that can work. We're actually adding some details to the Godot docs soon that you will be able to link to for macOS users to workaround limitations of un-notarized binaries. https://github.com/godotengine/godot-docs/pull/5105