By far the biggest problem I have with this game is cars that come from the top right (especially in the right lane) while the train is crossing. I have to just sit there with my mouse to make sure to stop those cars from hitting the train, which means I can't do anything else on the screen. Half of my games I lose this way. I need either a little more space to see where they're coming from, or for this to switch to right hand drive (or put the train track over the top left road, which allows a longer incoming lane to be seen on the screen) so at least there is a longer lane to see them coming into the intersection. There is about one car length of road there, which isn't enough time to see the car and stop it before it hits the train.
The other major complaint I have is that sometimes police cars hit the train. I can't stop either, so am I just doomed to lose when that combination comes up with the wrong timing?