I know the solution to 000 changes with each game although I have yet to see up up up. I am just about to play through again using the latest download and will see if I get a problem in the final area; can you please give a bit more of a clue to which location you mean with pipes?
At ... after you got the switch, and go in the karma portal at that location there is also a similar puzzle with horizontal and vertical lines, like in submachine one. I don't know what to call it, a pipe with three regulators which leads to sort of a big container. The clue clearly says horizontal horizontal horizontal, but it is the same as the starting position. I tried every possible combination and it wont open for me 2^3=8. (There is Karma Light flowing out , when you have them vertically).