Sorry you're having problems.
Unfortunately these errors often aren't the sort of things I as the developer can fix in the game itself, it relies on things being on your PC.
With this specific one what I can see by googling suggests that your antivirus software could be causing the issue, Link 2.
It seems like people also get this error if they don't extract the game files before trying to play, have you done that?
Also could I ask what your PC specs are?
If you can't get the game to run you can find out about itchio refunds here.