First I've heard of it! One of your keys might've just gotten stuck I think. Events generally don't trigger unless you actually move onto them using the game's controls.
Would certainly be interesting to see Mistyra and Arlene meet. Most likely they'd just double-team the player though XD.
Growing a cock is controlled by cock transformations I think. I can investigate it later, but if I recall, futa settings don't affect the player because I've separated gender from body configuration, so you can be considered male with a female body, and vice versa. Futa settings do affect NPCs though.
Be sure to practice responsible cheese throwing!