I was thinking about this, don't THINK it affects anything overall. but just wanted to double check something.
The fight against Edith has "limb detachment" as part of the fight, but you can skip it if that makes you uneasy. I'm very glad this is an option, because it does kind of bother me. So...I skip the tough fight against Edith and just go for the "save Transylvania all at once" angle. I miss a few things by skipping the limb detachment stuff, but want to make sure that I don't miss anything that alters interactions or something special by skipping the fight!
I do like how you mix what is primarily a fairly serious game with a LOT of humor. Random NPC comments, how various people treat holding hands (Sammy and Arlene are both great), catching the police chief with "important business"...fun stuff!
Curiosity question, are you wanting to have people show up when you work as a stripper? It might make things awkward as far as seeing Sammy or Lin Lin while you are doing a striptease, but also might be funny! (In the case of Arlene, scary-funny!)