Nice game, interesting balancing aspects that turned out quite nicely, I think.
I eventually ran out of slots to build as my population grew larger and larger (but the resource generators become more and more efficient with upgrades, so I was able to delete the excess ones).
With a large population the culture seems to drop faster than I was able to maintain it even having plenty of campuses (but everything else was fine, so my population didn't seem to mind much). I deliberately avoided the medicine upgrades, due to my overpopulation problems.
Made it to my new planet with >2m citizens.
Eventually having to click individual buildings for maintenance became quite tedious, maybe some kind of scheduling system would have been good for that (also making all research centres work on the same project with a single click might have been nice).
The UI is fantastic and I also enjoyed the opening cutscene a lot. Good job!