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"Windows cannot access the specified device, path, or file. You may not have the appropriate permissions to access the item"

Running as administrator makes no difference.

Windows 7 64 bit, 32GB RAM.

Hi. That looks like a Windows error message rather than a Lunar Jetman Remake (LJM) message. Please can you confirm that LJM is starting up and then failing. This can be done by first opening the game directory and then deleting the sys_log.txt file (if it exists). Next try running LJM again. Once it's failed check to see if the sys_log.txt file has then been created or not. Please let me know the outcome and we can take it from there.