Almost impossible to play, sadly. It's really hard to tell depth / position in an isometric perspective, so there needs to be a constant shadow or something to indicate where you're going to land after a jump.
The screen is also way too fast in the beginning. It should start slow, and slowly ramp up in speed. The powerups barely slow the screen down, and only for a very short time, making the learning curve frustratingly steep.
It's a cool concept though, and with some small refinements I could easily see it being really fun!