Sure thing, I'm playing on a 64 bit Windows 7 machine. It is an older PC (intel i7) but it has what should be more than enough ram (8gb), although the graphics card is old enough (Radeon HD 5570) that perhaps it is the problem.
For others reading on the crashes aren't a deal breaker so don't go running from the game as I wouldn't have played through 230 of the puzzles so far if I wasn't enjoying myself, but if the annoyance of them could be reduced it would definitely make things even better :)