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you could try to whitelist the game folder if the antivirus  support that feature..

Once you do that, make sure you have a correct Windows architecture and have the neccessary DLLs files to run the game.

And last thing: Change Itch IO game installation location to your hard drive root instead. Like C:\ItchGames or D:\ItchGames

Unzipped the 64bit version to root drive C:\ and it works perfectly! Thanks again for the help bluesaka111!