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I have answered this on Discord, but will also post here for anyone's future reference:

  1. The extension does indeed work on all platforms - since it doesn't do anything unordinary as far as file access goes, it is implemented entirely in GML using buffers and data structures.
  2. The extension has no hard limit on size - for example, Nuclear Throne translations tend to be just a little over 64KB. Processing time scales linearly with file size.