We played this today with four superheroes and our guide.
I think we saw the full spread of doom luck, with the first player being knocked out on his second roll and the second one not too long after, while the others kept hanging on. It's intriguing that helping someone increases the likelihood they'll be doomed.
We had a good time, but if running this, consider how you might let people who get removed early stay involved in the game.
Thanks for making the game <3