This has so much polish, it's amazing how many little details you got in. Even just the animations / tweens and transitions in the intro. You must have over 100 sprites, the painting tech for the puke; there's just so much going on and it's really really neatly tied together.
I enjoyed the game a lot, and it ended just at the right time as the mechanics were juuuust starting to feel samey. This is my run:
The power-up mechanics were nice in idea and I enjoyed choosing, but I didn't notice them personally. Perhaps would have liked their effects to be much stronger and dramatically change the gameplay. I, like many others I think, ran over as much of the office furniture first before puking to finish off the score, with the health reduction, it felt like I was punished more for using the main mechanic of the game over just running into stuff. But as you've mentioned in another comment, it's just a tuning thing, which is totally expected and frankly we've all struggled with it I think!
I did have a small issue on the tutorial; as I was wheeling about and getting used to the controls, I was running everything over. Just as I started to puke, I noticed there was some text about the fire extinguisher which I missed as it transitioned out of the tutorial, so I had to reload. It's a very small thing, but it was accidentality skippable at perhaps less predictable time.
I couldn't quite work out how you've done the 'painting' with the puke. I presume it's layered sprites and then modulating the furniture sprites affected? I really felt that the lean on Jimmy's sprite is really nice, it's tiny, but made the movement controller feel great.
This is highly enjoyable and doesn't outstay its welcome, and I think it's probably the entry with the highest quality polish on it that I've played so far. Thank you.