I really enjoyed this overall. The artstyle and music is great and complements the gameplay well.
Some of the powerups I haven't yet figured a good use for like for better sliding, since I only ever use the slide when using shortcuts. I'm also not sure if the game over screen ever showed me any other metric for how far I've actually gotten aside from the types of rooms visited in the run (that is in endless mode).
I think adding some feature to reverse mutation progress would make the endless mode a lot more interesting (and actually endless in theory) as you could stack powerups for longer and I would've loved to know how that would've affected my controls and overall gameplay.
One of my favorite entries thus far!