I Agree, that's why I haven't committed to a setting yet. I was thinking of modules in different settings. Keeping it flexible.
That's not a bad idea. As a total novice, I've been advised to kind of stick to a particular style or genre, but not be afraid to share with others if there's interest. For instance, I'm kind of trying to reach the Call of Cthulhu, horror audience, but if there was interest in a 5E version, I'd totally do it.
I'm thinking of the first non lore /"lore" book to have like 5 different settings. Each in a different genre. To showcase the games flexibility. And then afterwards bring out books that have like "lore modules " with each time a example one shot. But to make them all stand alones. You could have connections but thar shouldnt be the main focus.