Got a score of 5015 and depth 5 on the first time around! Took a bit of getting used to, but I really like the flow of it. The pixel debris flying around really adds a lot to the experience too! :)
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Biggest confusion I had was I thought keys did something on their own, so the first perk took was more keys. I only saw one chest through the whole run so the extra keys were kind of useless. Might be interesting if matching two keys spawned a chest? Don't know if that would break the balance of the game though haha