Art: Easy on the eyes. I'm personally not crazy about heavily-filtered photos as an art style, but I am also aware that some people are just fine with that. Good effort overall.
Writing: Pretty solid, I would say. Coral pox is scary. I guess if I have a complaint, I would have expected more about what these people actually believe. I gather that they believe in "shared conscience," but was that meant to be "consciousness"? I gather based on all the allusions that their theories have some roots in quantum mechanics. I'm probably an early prophet of the Quantum Lady myself, having my own theories of quantum consciousness.
Game Design: I like the decision not to default to an adventure module. I think it works well that you did a kind of "miscellany" in that you have a ship, a disease, a character class, some NPCs, some relics, etc. all thematically tied together, instead of just doing one of those things in great detail. It's like a salt shaker of religiosity that a Warden could sprinkle into their campaign whenever they need something interesting happening in the background. I'm a little confused about the Entanglers and Herba Oris though... are they all infected themselves? Or are they just carrying it and somehow immune to getting infected? Does ingesting it make you infected, or is it "safe" at that stage but contagious earlier on?
Theme: Very obviously myth and Mothership and Barrow.
Layout: Worthy of full marks but I would say the table with the stages of Herba Oris infection is not as tidy as the rest and looks like it just has its default settings... maybe needs some internal padding, color, etc.
Utility: Like I said, a salt-shaker of religiosity. Obviously requires some work from the Warden to implement things but that's to be expected. My main concern would be with the Entangler class, as playing something that's going to impose permanent negative consequences on the other players just by being there would be a no-no in many groups. The other classes' negative trauma responses are more in the moment.
Favorability: I dig it. I'm not so excited about it that I'm slotting in into a campaign at the next opportunity, but it's definitely one of the more interesting entries.