Heck yes I'd love being able to easily filter an arbitrary amount of tags, particularly when looking for Assets.
This works but is a bit clunky: https://itch.io/game-assets/tag-user-interface?exclude=tg.pixel-art
Viewing post in Tags to Exclude
I made this website for filtering games on itch.io with more filtering options. https://better-itch-search.kalrog.com/