>There is no actual difference between rolling a 'd100' or rolling '2d10 with one tens die and one ones die', this goes for any dice, digital or real.
I suppose I was taught incorrectly then. My understanding is that according to dice probability statistics all dice 'bend to their combined median' in results when multiple same-sided dice are introduced and that the probability curve becomes more a sin-wave the more dice are introduced but is only ever 'flat' when rolling a singular die. The median for a d100 is 50, where the medians for two d10s would be '5 and 5', which would leave me expecting 50s (and more specifically 55s) more often and for the 2d10s to skew very slightly towards the higher end of the table of possible results vs the much more neutrally weighted d100.
Any case, as goes 2d50: that's accounted for in my tables as in every table you don't get a different result when you roll a 1 versus a 2; I tried to keep it method agnostic so that it didn't matter what method was used.
I would caveat that with digital dice rollers, some use neutrally-weighted tables that treat every possible result of the given set of dice as equally likely, which would 'unbias' the dice. (Also some don't use particularly high quality RNGs -- but that's a separate matter entirely haha)