Hi! Thank you so much for this detailed feedback. This is exactly what I need to hear as I'm balancing the game for the full release.
I take your point about the collisions between different tiers being frustrating—I'll look into ways to make the reactions smoother. Also, I'll review the RNG and costs for Boron and Carbon, as it seems the difficulty curve is too steep right now.
My goal is to make the 'experiment' feel rewarding, not just a grind, so I'll definitely be tweaking these numbers in the next update. Thanks for playing long enough to reach those tiers and for helping me improve the game!