You did an excellent job recreating the old Windows interface (It's crazy that Windows 7 means nostalgia now, I'm getting old). The idea is really cool, you designed an interesting system of damage and defense. For a mouse based gameplay it's really unique.
I have to complain about the enemies' and their patterns. There seems to be a lot of rules to be followed in your game, but no one of them are explained. For example, there's no visual indicator to know if you hovered the cursor enough time over the exploding viruses to avoid the damage or there's no explanation about why the cursor starts to move out of control (I hope that's not a probel of my mouse hehe).
I'm not an expert about styilistic details, but Windows 7 has some well defined visuals and design elements. I think it woul've been cool if you'd recreated those details to create more cohesive visuals.
This was a pretty unique entry with a great approach to the jam's theme. Good job!