My point wasn't having 'lucky runs' in general, but having odds so bad there's a good chance you'll just never get the thing, ever. Although, personally, I'm never going to do the RNG and instead savescum every time - I don't care about guides or it being braindead but I do want a consistent experience that doesn't have me resetting or refreshing the page dozens of times.
And yeah, vitality potion makes you invincible to calamities. Haste ensures you don't die to fatigue or hunger (assuming you can find the bed). Either are pretty game-breaking, tbh; anything that breaks balance is still going to do so regardless of if you lock it behind rng.