Yeah, there are a number of the settings that don't change anything which includes the 'food fatigue' setting. I have like 10 packs of crackers that Dr. Kel won't eat and the only thing I can do with them is sell them.
Also, for the drone bag glitch with the cube: I don't know about the hotbar disappearing and being replaced by a cube, but I do know that if you stand too close to the detached drone bag when putting items into it, the item will instead appear in the bag as a cube and not the item that you put in. I go around this by making sure I am at max distance to interacting with the bag before putting anything into it.