Depends on how vanilla you want things to be.
The more perverted, kinky, depraved and taboo the sex gets, the more contortions needed in the narrative.
If the MC is a guy in an Office, or College... doing the rounds.. with the women... playing the field.... in ways that one might, proper consideration of power dynamics and imbalances, State regulations and workplace laws, company/institutional policies, etc etc.... the narrative can have solid substance.
If the MC is hate-fucking his twin sister, for the role of Harem leader, of a Harem that included his Submissive, painslut Bimbofied mother, his Aunt that is Bi switch, hetero Sub, Lez Dom with a thing for barely adult waif women including her own daughter, his College History professor with her Fantasy Cosplay kink, his BLACK Law Professor who loves being treated like a literal 19thC American Plantation Slave with not only the r*pe, but corporal punishment and dominance through violence, as well as his Doctor, whose got two gorgeous nurses, a hot AF receptionist, and a beautiful partner in her practice who she's all gotten secretly addicted to something to coerce in to being sexual service animals for the MC who she psychotically, obsessively, sexually worships as a God..... well, NO, you CANNOT do substance... at least REALISTIC substance too much. You both have to have moral contortions, tenuous associations and justifications, ultra unrealistic predicates, the flimsiest and longest bows being drawn to make it all happen, AND use it to sew together the copious amounts of depraved perverted sex.
Sorry, I TAKE THE LATTER EVERY TIME.
In ANY scenario WORTH my time, and I find the latter ones FAR MORE worth it than the former, the story is ALWAYS going to be subordinated to the Sex, and that comes at the expense of substance... and I AM SO THERE FOR THAT.