I tried it with the Day 22 Implant slimes and on day 26 getting a Game Over from one of the leaks, if you quit to Main Menu from the game over screen then try to go back into Story Mode the load screen sticks at 0% and doesn't progress (so you gotta restart). There is a chance this exists for all Game Overs.
Also on Day 22 you can spam the Jar Counterspell to undo the Implant slime growth (and not use the portal boob as a shield). Eventually the portal boob just jumps into the middle of the screen and rolls away like normal.