Thanks for playing. Yeah, it's a permadeath roguelite, you start every run with a new generation and from the start. Frankly, this isn't an issue in my eyes. Anyone who reads the storefront (here or on Steam) will see it's a roguelite, Demo Day is just an unique situation where people download the game without looking at any promo material.
I agree on the randomized introduction, I want to make a new tutorial that acts as the first level of the game. It'll give you some weak enemies to learn your alchemy on.
What if I add a stronger time slowdown when you enter alchemy mode? Would that make it more bearable, or is there something fundamentally wrong for you?