This is a realy addictive builder game... I love those roguelike kind of progression mechanics!
I bet this would have tons of scope for expanding with stuff like tech trees vs sprituality trees vs diplomacy trees, sort of like Civilisation, so you could craft each run with it's own path and identity. And then giving the player the old 1-of-3 things mechanic to help them improve and upgrade during the run.
We love choosing 1 of 3 things, so we made a deckbuilder. Would love your feedback on it if you wanted to give it a try for more roguelike fun!