This is a very well made game, and a very addictive one. I already played with it yesterday evening and couldn't stop until I reached the end (on Round 26 :P)
I'm not too familiar with the deckbuilder genre, but the first game came into my mind was the board game Quacks of Quedlinburg, especially due to the troublemaker pirates that make your whole hand go boom. Yours have a lot more abilities and possible combos, which was very fun to explore even if the idea itself is not completely new and the controls and gameplay are very limited.
Today I checked back just to see if there were any new features added since yesterday and already tried out some new combos and the random shop feature which is an other nice addition.
Thanks to your game I definitely see myself trying out other deckbuilder games in the future.
Well done!