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Brother, anime style is always very good, but the idea is more important that style! If you have a good idea, you even can use everything you want! 

There are even vastly different styles that all would qualify for being anime. Ghibli is a lot different from Crayon Shin-Chan and both look different from other styles.

I think they mostly have in common, that the characters do not look realistically like in old Marvel/DC comics. Plus, the eyes are usually bigger.

But you should choose what style you want, if the idea is good - it will be the perfect game! Idea + your favourable style