I did some testing and my results are the same as yours for all my American systems with TMSS.
I originally said I tested Genesis 2, the was a mistake. I thought I tested the standalone cart there but I must have been mistaken. I apologize.
Here are my full results:
1x Mega Drive 1 no TMSS - working
1x Genesis 1 no TMSS - working
2x Genesis 1 TMSS - not working
1x Mega Drive 2 - working
2x Genesis 2 - not working
1x Genesis 3 VA1 (mod to support 32x/CD) - not working
1x Genesis 3 VA2 - not working
All Genesis 2/3 and Mega Drive 2 have TMSS.
So, North American systems with TMSS are not working.
It's possibly something in the code.
Hoffman might be interested since it impacts flash carts too.