Hmm, It would be nice to get a sort of constant guideline or tracker that keep you updated on the "main" storyline and whatever side stuff you have that you should do/accomplish, cause a lot of the stuff in game are kind of free-roam, and it can get pretty confusing especially for first time players that don't have any extensive experience with all the things you can do in-game.
Also, it's very easy to get distracted with doing a bunch of stuff and just forgetting some of them due to the "sandbox" nature of the game, though that might just be me lol.
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I don't think there is a main storyline? If there is, I'm probably even more confused than you are, and I've played over 200 hours.
It's just a life sim. It happens to be on a college campus, but honestly, you can literally never go to class once and that's a perfectly valid way to play if you enjoy it more that way.